Table 3.
Top 30 Significant hypoMethylated DMRs in CR-HCC Tumor Tissues Compared with Adjacent Non-Tumor Tissues
| Chrom | No.CG | Meth.CR-HCC | Meth.APTs | Meth.Diff | Meth.p | Direction | Gene_Name |
|---|---|---|---|---|---|---|---|
| Chr11 | 3 | 0.773586 | 0.895064 | −0.12148 | 3.54E-31 | Hypo | |
| Chr11 | 3 | 0.773586 | 0.895064 | −0.12148 | 3.54E-31 | Hypo | |
| Chr11 | 3 | 0.773586 | 0.895064 | −0.12148 | 3.54E-31 | Hypo | TIRAP |
| Chr8 | 26 | 0.486188 | 0.855095 | −0.36891 | 4.99E-30 | Hypo | |
| Chr8 | 26 | 0.486188 | 0.855095 | −0.36891 | 4.99E-30 | Hypo | |
| Chr11 | 15 | 0.488482 | 0.765907 | −0.27743 | 2.59E-28 | Hypo | TNNI2 |
| Chr11 | 15 | 0.488482 | 0.765907 | −0.27743 | 2.59E-28 | Hypo | SYT8 |
| Chr9 | 2 | 0.101594 | 0.213265 | −0.11167 | 2.69E-26 | Hypo | SHC3 |
| Chr9 | 2 | 0.101594 | 0.213265 | −0.11167 | 2.69E-26 | Hypo | |
| Chr6 | 5 | 0.253251 | 0.379558 | −0.12631 | 5.70E-26 | Hypo | |
| Chr6 | 5 | 0.253251 | 0.379558 | −0.12631 | 5.70E-26 | Hypo | |
| Chr6 | 5 | 0.253251 | 0.379558 | −0.12631 | 5.70E-26 | Hypo | TFAP2A |
| Chr6 | 5 | 0.253251 | 0.379558 | −0.12631 | 5.70E-26 | Hypo | TFAP2A-AS1 |
| Chr11 | 10 | 0.022787 | 0.49504 | −0.4729 | 2.34E-24 | Hypo | |
| Chr11 | 10 | 0.022787 | 0.49504 | −0.4729 | 2.34E-24 | Hypo | PHLDB1 |
| Chr1 | 7 | 0.738378 | 0.866507 | −0.12511 | 1.51E-22 | Hypo | |
| Chr1 | 7 | 0.738378 | 0.866507 | −0.12511 | 1.51E-22 | Hypo | BAI2 |
| Chrx | 16 | 0.309552 | 0.631625 | −0.32207 | 2.37E-21 | Hypo | |
| Chrx | 16 | 0.309552 | 0.631625 | −0.32207 | 2.37E-21 | Hypo | ERAS |
| Chrx | 16 | 0.309552 | 0.631625 | −0.32207 | 2.37E-21 | Hypo | |
| Chrx | 16 | 0.309552 | 0.631625 | −0.32207 | 2.37E-21 | Hypo | |
| Chrx | 33 | 0.200289 | 0.435692 | −0.25939 | 5.65E-21 | Hypo | PCSK1N |
| Chrx | 33 | 0.200289 | 0.435692 | −0.25939 | 5.65E-21 | Hypo | |
| Chrx | 33 | 0.200289 | 0.435692 | −0.25939 | 5.65E-21 | Hypo | |
| Chrx | 33 | 0.200289 | 0.435692 | −0.25939 | 5.65E-21 | Hypo | |
| Chr17 | 15 | 0.33953 | 0.550398 | −0.21731 | 7.80E-20 | Hypo | ALOX12P2 |
| Chr17 | 15 | 0.33953 | 0.550398 | −0.21731 | 7.80E-20 | Hypo | AC027763.2 |
| Chr17 | 15 | 0.33953 | 0.550398 | −0.21731 | 7.80E-20 | Hypo | |
| Chr11 | 11 | 0.721749 | 0.836882 | −0.10649 | 1.44E-18 | Hypo | CTTN |
| Chr1 | 4 | 0.808155 | 0.910256 | −0.1021 | 2.90E-18 | Hypo | |
| Chr1 | 4 | 0.808155 | 0.910256 | −0.1021 | 2.90E-18 | Hypo | |
| Chr1 | 4 | 0.808155 | 0.910256 | −0.1021 | 2.90E-18 | Hypo | SLC45A1 |
Abbreviations: Chrom, chromosome number; DMR start, the starting position of DMR; DMR end, end position of DMR; no.CG, number of CpG sites in this region; meth.CR-HCC, the average methylation level of CR-HCC in this region; meth.APTs, average methylation level of APTs in this region; meth-diff, difference of mean methylation level between CR-HCC and APTs in the DMR region; meth-p, p value of the significance difference between CR-HCC and APTs in the DMR region; Direction, the mean methylation levels of CR-HCC in the DMR region, hyper (high), hypo (low), relative to APTs.