Fig. 2.

A schematic representation of the BRAT1 gene and protein. a BRAT1 protein is 821 amino acids in length, with the arrangement of the main domains: CIDE-N (N-terminal of an cell death-inducing DFF45-like effector) domain (light blue) and two HEAT (Huntingtin, Elongation factor 3, A subunit of protein phosphatase 2A, and TOR1) repeat domains (blue). A schematic view was adopted from reference no: [3]. b The chromatogram and schematic representation of wild-type and mutated sequences illustrate the disrupted acceptor splice site at position − 1 of intron 11, which leads to a frameshift in the cDNA sample