Table 5.

Armadillo repeat-containing 5 and MENIN immunostaining in tumors with allelic imbalance at chromosome 16p in multiple endocrine neoplasia type 1–related tumors

Patient ID	Tumor	ARMC5 expression (cytoplasm)				MENIN expression (nucleus)
		Tumor tissue		Peritumoral tissue		Tumor tissue		Peritumoral tissue
		INT	+Cell, %	INT	+Cell, %	INT	+Cell, %	INT	+Cell, %
P49	hPHPTa	1	80	1	100	2	60	3	100
P49	PNET	1	80	1	100	1	40	2	100
P80	PNET	1	15	2	100	1	3	2	100
P80	PNET	1	30	2	100	1	10	2	100
P80	nPHPT	2	90	2	100	2	20	3	100
P80	MAH	0	0	1	100	2	20	3	100
P80	PNET	2	60	2	100	3	70	3	100
P97	DCIS	2	50	2	100	3	90	3	100
P97	LNET	1	30	2	100	1	80	3	100
P97	RC	1	80	2	100	1	50	2	100
P97	hPHPT	2	70	2	100	3	90	3	100

Patient ID P80 carries pathogenic germline alterations in ARMC5 gene, c.1223A > G p.Q408R, and MEN1 gene c.941delG p.R314Rfs*54.

Abbreviations: ARMC5, armadillo repeat-containing 5; DCIS, breast ductal carcinoma in situ; hPHPT, hyperplasia of parathyroids; ID, identification; INT, intensity of staining; LNET, lung neuroendocrine tumor; MAH, macronodular hyperplasia of adrenal cortex; nPHPT, nodular hyperplasia of parathyroids; PNET, pancreatic neuroendocrine tumor; RC, rectal carcinoma.

^a Tumor without loss of heterozygosity at chromosome 11q.