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Physicochemical Characterization of RPT-Loaded NPs
| Sample | Particle Size (nm) | PDI | ZP (mV) | EE (%) | DL (%) |
|---|---|---|---|---|---|
| RPT/PLGA NPs | 150 ± 7 | 0.16 ± 0.05 | −23.8 ± 0.8 | 85 ± 8 | 8.5 ± 0.4 |
| RPT/PLGA-PEG NPs | 136 ± 9 | 0.10 ± 0.01 | −19.4 ± 0.6 | 90 ± 6 | 7.3 ± 0.8 |
Abbreviations: RPT, rifapentine; PLGA, poly-d,l-lactide-co-glycolide; PEG, poly ethylene glycol; NPs, nanoparticles; PDI, polydispersity index; ZP, zeta potential; EE, encapsulation efficiency; DL, drug loading.
