Table 4.
Pharmacokinetic Parameters in Different Groups
| Parameter | Rifapentine | ||
|---|---|---|---|
| Free | PLGA NPs | PLGA-PEG NPs | |
| Cmax (μg/mL) | 8.12±0.26 | 9.25±0.23 | 7.95±0.31 |
| Tmax (h) | 10.00±0.00 | 38.40±0.00 | 60.00±0.00 |
| t1/2 (h) | 19.60±0.70 | 66.53±2.15 | 107.45±3.56 |
| AUC0–∞ (μg/mL h) | 266.35±1.30 | 834.24±2.73 | 1137.74±5.90 |
| MRT (h) | 26.18±1.21 | 85.28±3.10 | 135.82±3.14 |
Abbreviations: PLGA, poly-d,l-lactide-co-glycolide; PEG, poly ethylene glycol; NPs, nanoparticles; Cmax, maximum concentration; Tmax, time to reach peak plasma concentration; t1/2, half-life; AUC0–∞, area under the curve from 0 to ∞; MRT, mean residence time.