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. 2016 Nov 28;138(51):16669–16676. doi: 10.1021/jacs.6b08801

Figure 3.

Figure 3

Mechanistic investigation of the formation of a mixed anhydride from Val-NCA 1 and octanoic acid. (a) (a) Schematic of the reaction between 1 and either 16O-enriched or 18O-enriched octanoic acid with observable [M – H]–1 ions. (b) MS/MS product ion spectra highlighting the isolated 16O-enriched species and its fragmentation product. (c) MS/MS product ion spectra highlighting the isolated 18O-enriched species and their fragmentation products.