Table 2.

Primary outcome

Variable	n (DRIFT:standard)	DRIFT Mean (SD) or n (%)	Standard Mean (SD) or n (%)	Crude difference (95% CI), p value	Adjusted difference (95% CI), p value*
Primary outcome
Cognitive ability quotient	27:24	69.33 (30.06)	53.68 (35.70)	15.65 (−2.86 to 34.16), 0.096†	23.47 (6.23 to 40.71), 0.009†
Sensitivity analyses
Cognitive ability quotient‡	29:26	64.55 (34.04)	49.55 (37.22)	15.00 (−4.28 to 34.27), 0.125†	22.33 (4.77 to 39.89), 0.014†
Alive and without severe cognitive disability§	29:26	21 (72%)	11 (42%)	3.58 (1.16 to 11.04), 0.026¶	9.96 (2.12 to 46.67), 0.004¶
Alive and without severe cognitive disability**	32:31	21 (66%)	11 (35%)	3.47 (1.23 to 9.78), 0.019¶	7.69 (1.96 to 30.11), 0.003¶

*Adjusted for sex, birth weight and grade of IVH.

†Linear regression (difference in means).

‡Giving children who have died post 2 years a score of 0.

§Including all 4 deaths after 2 years as a negative outcome.

¶Logistic regression (OR).

**Including all 12 deaths as a negative outcome (akin to the study results at 2 years).

DRIFT, drainage, irrigation and fibrinolytic therapy; IVH, intraventricular haemorrhage.