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. 2020 Sep 4;142(15):1408–1421. doi: 10.1161/CIRCULATIONAHA.119.045158

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© 2020 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 4. — Expression of top-priority candidate genes in human cardiac cell cultures.

Human cardiac cells were cultured and stimulated in serum-free conditions. After stimulation, RNA was collected, and candidate gene expression was detected by quantitative polymerase chain reaction, relative to 18S/10 000 expression. Data show means, and error bars show standard deviation; n=3 biological replicates. Prohypertrophic (phenylephrine, isoproterenol, ET-1), fibrotic (TGFB), or inflammatory (IL1B). ANGPT2 indicates angiopoietin-2; CF, cardiac fibroblast; CM, cardiac myocyte; Ctrl, control; EC, endothelial cell; FSTL3, follistatin-related protein 3; IL1B, interleukin 1β; ISO, isoproterenol; LTBP4, latent transforming growth factor beta binding protein 4; NPPB, NT-proBNP/BNP; PE, phenylephrine; Rel. Exp., relative expression; SMC, smooth muscle cell; TGFB, transforming growth factor-B; THBS2, thrombospondin-2; and TNNT2, troponin T.