Figure 2.

Dose finding in groups 3 and 5. *Missing data on blood pressure, in the dose-finding approach considered to be normal in the absence of evidence of hypotension; #missing data on intubation score, effective sedation only judged by pre-intubation sedation level. In group 5, the 1.0 and 1.5 mg/kg dosing subgroups both contain six instead of five patients. This was due to initial uncertainty of the suitability of the data for the primary outcome in one patient in both subgroups. An extra patient in both groups was included to ensure of total of five patients with viable data on the primary outcome. After re-evaluation the data of all six patients in both subgroups turned out to be suitable.