Table 1.
Patient characteristics
| Characteristic | Entire study population (n=91) |
Group 1 (n=18) | Group 2 (n=8) | Group 3 (n=25) | Group 4 (n=10) | Group 5 (n=26) | Group 6 (n=1) | Group 7 (n=2) | Group 8 (n=1) |
| Gestational age (week), median (IQR) | 27.7 (25.9–30.6) |
25.3 (24.8–25.6) | 24.8 (24.4–25.6) | 28.0 (26.9–28.9) | 26.8 (26.3–27.1) | 32.0 (30.4–33.6) | 30.7 | 38.1 | 37.9 |
| Birth weight (g), median (IQR) | 1045 (825–1560) |
720 (634–864) | 740 (716–791) | 1045 (890–1223) | 938 (886–1076) | 1678 (1480–2129) | 1290 | 3845 | 2865 |
| Birth weight <10th percentile, n (%) | 23 (25) | 5 (28) | 0 | 8 (32) | 1 (10) | 8 (31) | 1 (100) | 0 | 0 |
| Postnatal age (hour), median (IQR) | 29 (9–213) |
129 (38–173) | 405 (384–681) | 10 (6–31) |
371 (307–524) | 20 (5–26) |
432 | 50 | 593 |
| Actual weight (g), median (IQR) | 1100 (830–1560) |
705 (643–838) | 923 (825–1084) | 1065 (910–1193) | 1105 (925–1123) | 1678 (1460–2125) | 1400 | 3848 | 3100 |
| Male gender, n (%) | 58 (64) | 12 (67) | 7 (88) | 13 (52) | 6 (60) | 16 (62) | 1 (100) | 2 (100) | 1 (100) |
| Reason for intubation, n (%) | |||||||||
| RDS | 44 (48.4) | 2 (11.1) | 0 | 17 (68) | 0 | 23 (88.5) | 0 | 2 (100) | 0 |
| Apnoea | 19 (20.9) | 9 (50) | 5 (62.5) | 2 (8) | 3 (30) | 0 | 0 | 0 | 0 |
| Sepsis/NEC | 11 (12.1) | 5 (27.8) | 1 (12.5) | 3 (12) | 1 (10) | 1 (3.8) | 0 | 0 | 0 |
| Respiratory insufficiency | 13 (14.3) | 1 (5.6) | 2 (25) | 3 (12) | 4 (40) | 2 (7.7) | 0 | 0 | 1 (100) |
| Elective* | 2 (2.2) | 0 | 0 | 0 | 1 (10) | 0 | 1 (100) | 0 | 0 |
| Other | 2 (2.2) | 1 (5.6) | 0 | 0 | 1 (10) | 0 | 0 | 0 | 0 |
| Propofol starting dose (mg/kg), n (%) | |||||||||
| 0.5 | 1 (1) | 1 6) | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 1.0 | 30 (33) | 4 (22) | 5 (63) | 5 (20) | 6 (60) | 6 (23) | 1 (100) | 2 (100) | 1 (100) |
| 1.5 | 23 (25) | 5 (28) | 3 (37) | 5 (20) | 4 (40) | 6 (23) | 0 | 0 | 0 |
| 1.75 | 9 (10) | 0 | 0 | 5 (20) | 0 | 4 15) | 0 | 0 | 0 |
| 2.0 | 26 (29) | 6 (33) | 0 | 10 (40) | 0 | 10 (38) | 0 | 0 | 0 |
| 2.5 | 2 (2) | 2 (11) | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
*Including prior to surgery or tube exchange.
NEC, necrotising enterocolitis; RDS, Respiratory Distress Syndrome.