Table 1.
Genes implicated in DCM
| Gene | Protein |
|---|---|
| Sarcomere | |
| MYH6† | α-Myosin heavy chain |
| MYH7*† | β-Myosin heavy chain |
| TPM1*† | α-Tropomyosin |
| ACTC1*† | α-Cardiac actin |
| TNNT2*† | Cardiac troponin T |
| TNNC1* | Cardiac troponin C |
| TNNI3† | Cardiac troponin I |
| MYBPC3† | Myosin-binding protein C |
| TTN*† | Titin |
| Z disk | |
| ACTN2† | α-Actinin 2 |
| BAG3*† | BCL2-associated athanogene 3 |
| CRYAB | α-B-crystallin |
| TCAP† | Titin-cap/telethonin |
| MYPN | Myopalladin |
| CSRP3† | Muscle LIM protein |
| NEXN*† | Nexilin |
| ANKRD1† | Cardiac ankyrin repeat protein |
| LDB3*† | Cypher/ZASP |
| NEBL | Nebulette |
| Cytoskeleton | |
| DES*† | Desmin |
| VCL*† | Metavinculin |
| FLNC | Filamin C |
| Desmosomes | |
| DSC2 | Desmocollin 2 |
| DSG2† | Desmoglein 2 |
| DSP*† | Desmoplakin |
| Dystrophin complex | |
| DMD*† | Dystrophin |
| DTNA | α-Dystrobrevin |
| SGCD† | δ-Sarcoglycan |
| ILK | Integrin-linked kinase |
| FKTN† | Fukutin |
| Ion channels | |
| SCN5A*† | Type V voltage-gated cardiac Na channel |
| ABCC9† | Sulfonylurea receptor 2A, component of ATP-sensitive potassium channel |
| HCN4 | Hyperpolarization-activated cyclic nucleotide-gated potassium channel 4 |
| Sarcoplasmic reticulum and cytoplasm | |
| PLN*† | Phospholamban |
| RYR2 | Ryanodine receptor 2, Ca channel |
| DOLK | Dolichol kinase |
| RAF1† | Proto-oncogene |
| Nuclear envelope | |
| LMNA*† | Lamin A/C |
| EMD | Emerin |
| TMPO† | Lamin-associated polypeptide 2 |
| SYNE1/2 | Nesprin 1/2 |
| Nucleus | |
| EYA4† | Eyes absent 4 |
| PRDM16 | PR domain containing 16 |
| TBX20 | T-box 20 |
| RBM20*† | RNA-binding protein 20 |
| GATAD1 | GATA zinc finger domain protein 1 |
| NKX2-5† | Cardiac-specific homeobox 1 |
| LRRC10 | Leucine-rich repeat containing 10 |
| Mitochondria | |
| TAZ/G4.5† | Tafazzin |
| TXNRD2 | Thioredoxin reductase 2 |
| Lysosome | |
| LAMP2† | Lysosome-associated membrane protein 2 |
| Extracellular matrix | |
| LAMA4 | Laminin 4 |
| Other | |
| CHRM2 | Cholinergic receptor muscarinic 2 |
| MIB1 | Mitogen-activated protein kinase kinase 2 |
| TTR | Transthyretin |