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. 2020 Sep 15;37(11):4519–4537. doi: 10.1007/s12325-020-01499-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 3 — Functional MCs are required for proper wound healing. Wound healing progress was evaluated over a 10-day period in non-DM and DM mice DSCG treated or not treated and MC-deficient mice. a, b Wound healing was delayed in C57BL6 DM mice compared to non-DM mice and DSCG pre-treatment accelerated it from days 6 to 10 post wounding. DSCG had no effect on non-DM mice. c–f Wound healing was delayed in KitW/KitW-v mice with or without DM, when compared to their respective non-DM or DM WBB6F1 controls. Topical SP improved healing at day 10 post wounding in both non-DM and DM WBB6F1 mice, but failed to have an effect in either non-DM KitW/KitW-v or DM KitW/KitW-v mice. g, h Wound healing was delayed in MC-deficient KitW-sh/KitW-sh mice when compared to their respective B6.Cg controls. *p < 0.05. (Ref. [77])