Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 10;6:100. doi: 10.1038/s41420-020-00337-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — Mutp53 can influence transcription level of Her2, and as a result stabilize Her2. Mutp53 physically interacts with and enhances the transcriptional activity of HSF1, which is the main transcriptional regulator of Hsp90. Hsp90 stabilizes Her2 and mutp53 itself. Moreover, Her2 inhibitor lapatinib inhibits the ternary Her2–HSF1–mutp53 interaction, which leads to the destabilization of the mutp53 protein in cancer cells.