Figure 3.

Phenotypes associated with myocardial infarction (MI) in Comparative Toxicogenomics Database. A partial screenshot of the “Phenotypes” data-tab for MI lists the phenotypes that have an inferred relationship to this disease via either a Chemical Inference Network or Gene Inference Network. Here, 198 chemicals have direct interactions with both the phenotype “apoptotic process” (evidence line No. 2) and the disease MI (evidence line No. 3); independently, 17 genes also interact with both this phenotype (evidence line No. 4) and disease (evidence line No. 5). Thus, “apoptotic process” can be inferred to MI via 198 chemicals and 17 genes. Note: 5 of the 198 chemicals listed are environmental ambient air pollutants (boxed within the Chemical Inference Network).