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. 2020 Jul 14;177(2):392–404. doi: 10.1093/toxsci/kfaa113

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Figure 7. — Assembling CGPD-tetramers. Intermediary genes and phenotypes derived from CGPD-tetramers are coalesced and assembled into putative chemical-induced disease pathways to help inform the knowledge gaps connecting ozone (O₃) exposure with myocardial infarction (MI) using steps at the molecular, cellular, and system levels. The number of genes (circles) associated with each set of phenotypes is indicated, and phenotype clusters (boxes) are interrelated by shared genes (curved arrows with lists of shared genes), helping to conjoin independent tetramers into a larger integrated network relating ozone exposure to cardiovascular disease. The diagram uses 84 CGPD-tetramers (from Figure 6) linking ozone, 33 genes, 24 phenotypes, and MI.