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. 2020 Oct 7;13:9991–10000. doi: 10.2147/OTT.S268214

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© 2020 Bao et al.

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miR-135b-5p suppresses cell proliferation in HCC cells. (A) The effect of miR-99b, miR-101, miR-135b-5p, miR-373-3p, and miR-375 on proliferation of SK-hep1 and HA22T cells. The MTT cell proliferation assay revealed that miR-135b-5p significantly suppressed HCC cell proliferation in SK-hep1 and HA22T cells. (B) The effect of miR-135b-5p on proliferation of HepG2, SNK and Huh7. The MTT proliferation assay revealed that miR-135b-5p significantly suppressed HCC cell proliferation in HepG2, SNK and Huh7. (C) The effect of miR-135b-5p on colony formation of HCC. (D) The number of colonies was counted. The colony formation assay showed that miR-135b-5p significantly suppressed HCC cell colony formation in SK-hep1, HA22T, HepG2, SNK, and Huh7. *p < 0.05, **p < 0.01.