Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 7;13:9991–10000. doi: 10.2147/OTT.S268214

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Bao et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

miR-135b-5p suppresses the expression of HIF-2α and c-Myc protein but increases the expression of p27 protein in HCC cells SK-hep1 and HA22T. (A) Effect of overexpression of miR-135b-5p on HIF-2α in SK-hep1 and HA22T cells. Western blot analysis revealed that miR-135b-5p suppressed the expression of HIF-2α in SK-hep1 and HA22T cells, but was unable to suppress the expression of HIF-2α in AR-overexpressing SK-hep1 and HA22T cells. (B) Effect of overexpression of miR-135b-5p on c-Myc and p27 in SK-hep1 and HA22T cells. Western blot analysis revealed that miR-135b-5p suppressed the expression of c-Myc and increased the expression of p27, however, in AR-overexpressing SK-hep1 and HA22T cells miR-135b-5p was unable to suppress the expression of c-Myc or increase the expression of p27. (C) TC-S suppresses the increase in HCC proliferation in AR-overexpressing SK-hep1 and HA22T cells. (D) TC-S suppresses the expression of c-Myc protein but promotes the expression of p27 protein in AR-overexpressing SK-hep1 and HA22T cells. **p < 0.01, ^##p < 0.01.