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A-D) CMS initiated vertebral endplate damage in the C6/7 segment. (A) The safranine O/fast green staining of C6/7 vertebral endplates. (B) The histological grades evaluate between the CMS and sham groups at 4, 8, and 12 weeks. (C, D) Representative pSmad2/3 staining and TRAP staining of C6/7 vertebral endplates. “*” indicated P < 0.05 compared with the sham group. CMS = cervical muscle section; TRAP = tratrate resistant acid phosphatase.
