Figure 1.

https://www.lucidchart.com/documents/edit/7d360b60-6bb2-4b23-98be-406dc2fdb9f6/0?callback=close&name=docs&callback_type=back&v=1924&s=612A simplified diagram of the health state transitions used in the Markov model. The specific acute and chronic toxicities (GI Grade 2, GI Grade ≥3, GU Grade 2, and GU Grade ≥3) are not shown, but were included in the model as part of the relapse free acute and chronic side-effects states. The acute side-effects health state was used only for the first cycle and the late side-effects health state was used for cycles 2–15. CA, cancer; GU, genitourinary ; RF, relapse free; SE, side-effects