Exemplary treatment plan comparison in a young patient with craniopharyngioma. A: 3D-CRT with photons, B: IMRT (VMAT) with photons, C: PRT with two opposing beams. Highlighted OAR: Brain stem. IMRT, intensity modulated radiation therapy; OAR, organ at risk; PRT, proton beam radiotherapy; VMAT, volumetric modulated arc therapy