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Microsomal stability of RDV and RMP in lung, liver, and kidney.
| Tissue | RDV | RMP | ||
|---|---|---|---|---|
| t1/2 | CLint | t1/2 | CLint | |
| Lung | 10.95 ± 0.69 | 127 ± 8 | 5.42 ± 0.95 | 261 ± 44 |
| Liver | 0.80 ± 0.08 | 1740 ± 162 | 4.94 ± 1.80 | 304 ± 33 |
| Kidney | 1.11 ± 0.06 | 1253 ± 71 | 2.73 ± 0.41 | 517 ± 85 |
Units: t1/2: min; CLint: mL/(min∙g microsomal protein).
