Figure 9.

No persistent motor effects are induced by in vivo optogenetic stimulation in chronic 6-OHDA-lesioned mice. a, Slopegraph showing the size and reversibility of motor responses induced by optogenetic stimulation of PV⁺ neurons in naïve (gray dotted lines) and chronic 6-OHDA-lesioned mice (red dotted lines). Ten trials (circles) were run on each mouse. Trial numbers are denoted by colors (rainbow). Data from sustained (naïve: n = 12; 6-OHDA: n = 14) and patterned (naïve: n = 12; 6-OHDA: n = 14) stimulation are combined. The slope of each line shows the magnitude and direction of change. b, A plot showing the motor activity of a subset of chronic 6-OHDA-lesioned mice (n = 4) across time. Blue bar indicates the duration of light delivery; 10 stimuli were delivered. Black solid trace is the average distance from all mice; the shaded area shows the SEM. Black dotted trace is a representative example from a single mouse; data were scaled to facilitate comparison.