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. 2020 Oct 7;40(41):7837–7854. doi: 10.1523/JNEUROSCI.2487-19.2020

Figure 1.

Figure 1.

Lesion of the pPVT by KA injection modulates neuropathic pain. A, The drawing showing the rostro-caudal extent of KA injection (black). B1, B2, The NeuN-labeled neurons in SNI + KA in the pPVT (white dotted outline in B1). B–D, Representative images from the same rat as A. C1, C2, The GFAP-labeled astrocytes in SNI + KA in the pPVT. D1, D2, The merged pictures of B, C. E1, E2, The NeuN-labeled neurons in SNI + saline in the pPVT (white dotted outline in E1). F1, F1, The GFAP-labeled astrocytes in SNI + saline in the pPVT. G1, G1, The merged pictures of E, F. Scale bars = 100 µm (D1, G1; applied in B1, C1, E1, F1) and 50 µm (D2, G2; applied in B2, C2, E2, F2). H, Quantitative analysis of the number of NeuN-labeled neurons in the pPVT; *p < 0.001, SNI + KA versus SNI + saline. I, The PWTs in rats by von Frey tests from the post-SNI operation days 4–28 (n = 6 in each group); +++p < 0.001, SNI versus sham; *p < 0.05, SNI + KA versus SNI + saline; ##p < 0.01, ###p < 0.001, SNI + KA versus sham.