Fig. 1.

Axial images from gadolinium-enhanced T1 magnetic resonance imaging of the brain showing the ring-like glioma appearance in the mesencephalon before initiation of trametinib monotherapy (A); partial response 3 months after initiation of trametinib monotherapy (B); confirmed partial response 5 months after initiation of trametinib monotherapy, before the addition of low-dose dabrafenib (C); complete response 4 months after initiating the combination of trametinib and low-dose dabrafenib (D); confirmed complete response 7 months after initiating the combination of trametinib and low-dose dabrafenib (E). The patient has a ventriculoperitoneal shunt for hydrocephalus.