Table 1.

Pros and cons of screening before and after 24 h of age.

<24 h of Age	>24 h of Age
Increased detection of significant and major CHD	Increased detection of significant and major CHD
Optimal for prevention of postnatal hypoxia	Not optimal but still prevents some hypoxic events
Higher false positive rate for CCHD (0.5%)	Lower false positive rate for CCHD (0.05%)
Detection of other pathology (up to 50% of all false positives)	Detection of other pathology (up to 50% of all false positives)
Often still in hospital: doesn’t disrupt discharge process	May disrupt discharge process

CHD: congenital heart disease; CCHD: critical congenital heart disease.