Table 3.

DRR ≥3 months and ≥6 months for each subclassification model

	Low burden (at the time of diagnosis as intermediate-stage HCC)	High burden (group A: at the time of diagnosis as intermediate-stage HCC)	High burden (group B: progressed from low burden)	High burden (group A + B)
Model 1 (up-to-seven criteria) Child-Pugh A
DRR ≥3 months	46.4%	39.5%	28.6%	38.7%
DRR ≥6 months	26.2%	15.1%	7.1%	14.5%
Child-Pugh B
DRR ≥3 months	56.3%	22.7%	0.0%	22.2%
DRR ≥6 months	18.8%	9.1%	0.0%	8.7%
Model 2 (five-seven criteria) Child-Pugh A
DRR ≥3 months	46.5%	34.7%	23.1%	32.3%
DRR ≥6 months	24.5%	9.9%	15.4%	11.0%
Child-Pugh B
DRR ≥3 months	37.1%	24.0%	0.0%	23.1%
DRR ≥6 months	14.3%	8.0%	0.0%	6.9%
Model 3 (seven lesions criteria) Child-Pugh A
DRR ≥3 months	45.8%	34.4%	21.4%	31.4%
DRR ≥6 months	23.5%	10.0%	14.3%	11.0%
Child-Pugh B
DRR ≥3 months	37.8%	21.7%	0.0%	20.8%
DRR ≥6 months	16.2%	4.3%	0.0%	3.6%

DRR, durable response rate; HCC, hepatocellular carcinoma.