. Author manuscript; available in PMC: 2020 Oct 12.

Published in final edited form as: J Pathol. 2020 Jul 1;251(4):378–387. doi: 10.1002/path.5472

Table 5.

SDHB-IHC interpretations of a panel of experienced researchers versus local pathologists in cohort 1b.

	Local	Panel^#	p-value
Sensitivity [%]	80.0 [16/20]	65.0 [13/20]	0.250
Specificity [%]	92.4 [61/66]	98.5 [65/66]	0.125
Accuracy [%]	89.5 [77/86]	90.7 [78/86]
# Inconclusive/non-informative cases ^*	9	11
	Agreement amongst panel			Agreement of panel [>2/3] with local interpretations
	3	2	0
non-SDHx (n = 73)	62	9	2	63 [86.3%]
SDHx (n = 30)	21	6	3	19 [70.0%]
SDHx VUS (n = 2)	2	0	0	1 [50.0%]
Total (n = 105)	85	15	5	83 [79.0%]

Inconclusive cases were removed from the analysis.

For the panel of experienced researchers, interpretations where at least two out of three researchers agreed, were used.

VUS, Variant of Unknown Significance.