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. 2020 Oct 12;6:102. doi: 10.1038/s41420-020-00338-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A The Drp1 wt vector induced Drp1 protein overexpression (Drp1-OE) in HT22 cells. B Drp-OE did not induce obvious cytotoxicity in HT22 cells. C Drp1-OE reversed the cannabinoid CB1 agonist ACEA-induced restoration of cell viability. D Drp1-OE reversed the ACEA-induced inhibition of LDH release. E The Drp1-OE-induced effects on cell apoptosis were measured by flow cytometry. F Drp1-OE reversed the ACEA-induced inhibition of cell apoptosis. G Drp1-OE reversed the ACEA-induced effect on cleaved caspase-3 expression. *p < 0.05; NS no significance.