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. 2020 Oct 12;6:102. doi: 10.1038/s41420-020-00338-3

Fig. 4. Drp1 overexpression abolished the ACEA-induced effects on mitochondrial fission, fission-associated protein expression, and mitochondrial function in HT22 cells exposed to OGD/R.

Fig. 4

A Representative images of neuronal dendrites expressing Mito-DsRed, a mitochondrial marker. B Statistical results of the images in (A). C Western blot results showing Drp1, Fis1, and Mff expressions. D Drp1 overexpression (Drp1-OE) abolished the cannabinoid CB1 agonist ACEA-induced effect on Drp1 expression. E Drp1-OE abolished the ACEA-induced effect on Fis1 expression. F Drp1-OE abolished the ACEA-induced effect on Mff expression. G, H. Drp1-OE reversed the ACEA-induced effects on the activities of mitochondrial complexes I and IV in HT22 cells. Bar = 1 µm; *p < 0.05; NS no significance.