Table 1.
Activity of PM against promastigotes and intracellular amastigotes of L. amazonensis reference strain M2269 and ER256 clinical isolate.
| Promastigotea |
Amastigoteb |
SI | Infection (%)d | |||
|---|---|---|---|---|---|---|
| EC50c | EC90 | EC50 | EC90 | |||
| L. amazonensis M2269 | 145.23 ± 23.04 | 730.4 | 61 ± 9.48 | 111.9 | 8.6 | 66% |
| L. amazonensis ER256 | 9.98 ± 2.97 | 101.8 | 0.54 ± 0.11 | 4.86 | 993.7 | 59% |
SI: Selectivity Index, which corresponds to the ratio between the CC50 and EC50 values of intracellular amastigotes. The CC50 value for BMDM was 536.6 ± 27.1 μM.
a
Three independent experiments carried out in triplicate per strain/isolate.
b
Three independent experiments carried out in duplicate per strain/isolate.
c
EC50 ± standard deviation in μM.
d
Percentage of infected BMDM.