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. 2020 Aug 11;295(41):14084–14099. doi: 10.1074/jbc.RA120.013031

Figure 3.

Figure 3.

Effects of LRAs on in vitro cell viability and expression of cell activation markers. A, representative flow cytometry data showing Jurkat cell apoptosis, as measured by annexin V detection. Values indicate percentage of annexin-positive cells. B, dose-response profiles of panobinostat, prostratin, KA, and anthralin on apoptosis in Jurkat cells. Data are presented as -fold increase in annexin V–positive cells relative to cells treated with 0.1% DMSO (dotted line). C and D, representative flow cytometry data showing Jurkat cells stained for CD69 (C) or CD25 expression (D). Values indicate percentage of CD69- or CD25-positive cells, respectively. E and F, dose-response profiles of LRAs on CD69 (E) and CD25 (F) expression in Jurkat cells. Data are presented as -fold increases in each marker relative to cells treated with 0.1% DMSO (dotted lines). Error bars, S.D.