Table 1.
Relative activities of LRAs in vitro. Data are presented as relative EC50 values (in µm) normalized to the average GFP response for 10 μm prostratin (i.e. the concentration required to induce 50% of the signal observed by 10 μm prostratin) (21)
| Cell line | Prostratin | Panobinostat | KA | Anthralin |
|---|---|---|---|---|
| µm | µm | µm | µm | |
| J-Lat 9.2 | 5.4 ± 1.4 | 0.14 ± 0.02 | 10.4 ± 1.0 | 12.1 ± 1.7 |
| J-Lat 8.4 | 5.0 ± 0.9 | 0.46 ± 0.12 | 7.4 ± 2.6 | 12.6 ± 1.9 |
| J-Lat 10.6 | 1.9 ± 0.9 | 0.64 ± 0.09 | 16.0 ± 5.5 | 16.2 ± 1.2 |
| OM10.1 | 2.7 ± 1.0 | 1.6 ± 0.5 | >30 | >30 |