Table 1.
Variable | Absolute concentration (mean ± SD) |
Difference PB – BL (% mean change) | Difference RS – BL (% mean change) | ||
---|---|---|---|---|---|
Baseline (BL) | Placebo (PB) | Rosuvastatin (RS) | |||
Total cholesterol, mmol/L | 6.17 ± 0.47 | 6.16 ± 0.44 | 3.81 ± 0.33 | −0.01 ± 0.06a (−0.16) | −2.36 ± 0.14e (−38.25) |
LDL-cholesterol, mmol/L | 4.57 ± 0.32 | 4.56 ± 0.30 | 2.18 ± 0.19 | 0.01 ± 0.06a (0.22) | −2.39 ± 0.13e (−52.29) |
HDL-cholesterol, mmol/L | 1.175 ± 0.15 | 1.186 ± 0.14 | 1.273 ± 0.16 | 0.011 ± 0.02a (0.93) | 0.098 ± 0.02b (8.34) |
Apolipoprotein B-100, nmol/L | 322.34 ± 46.91 | 321.90 ± 47.52 | 175.02 ± 19.15 | −0.44 ± 4.54a (−0.13) | −147.31 ± 31.24c (−45.70) |
Apolipoprotein A-1, nmol/L | 37.11 ± 3.44 | 37.17 ± 3.50 | 39.17 ± 3.47 | 0.05 ± 0.28a (0.13) | 2.06 ± 0.14e (5.55) |
Triglycerides, mmol/L | 0.93 ± 0.078 | 0.94 ± 0.063 | 0.74 ± 0.065 | 0.01 ± 0.03a (1.08) | −0.19 ± 0.02d (−20.43) |
Phospholipids, mmol/L | 2.45 ± 0.10 | 2.46 ± 0.12 | 1.78 ± 0.05 | 0.01 ± 0.03a (0.41) | −0.67 ± 0.06d (−27.35) |
Total fatty acids, mmol/L | 13.11 ± 0.54 | 13.17 ± 0.50 | 9.16 ± 0.28 | 0.06 ± 0.22a (−0.46) | −3.95 ± 0.29e (−30.13) |
Total free fatty acids, μmol/L | 683.55 ± 29.58 | 682.06 ± 26.17 | 537.22 ± 18.36 | −1.49 ± 9.54a (−2.18) | −146.33 ± 18.12d (−21.41) |
ap > 0.05; bp < 0.001; cp < 0.0001; dp < 0.00001; ep < 0.000001.