Table 2.
The effect of rosuvastatin treatment on the concentration of each fatty acid in total plasma.
| Fatty acid | Absolute concentrationa, μmol/L (Relative concentration, %) |
Change from baseline (% mean change) | Effect, p value | |
|---|---|---|---|---|
| Baseline | Rosuvastatin | |||
| Dodecanoic acid (C12:0) | 127.17 ± 7.52 (0.97) | 64.85 ± 6.75 (0.71) | −62.33 ± 5.58 (−49.01) | <0.00001 |
| Tetradecanoic acid (C14:0) | 302.85 ± 29.43 (2.31) | 153.92 ± 11.45 (1.68) | −148.93 ± 19.64 (−49.18) | <0.00001 |
| Pentadecanoic acid (C15:0) | 43.26 ± 2.40 (0.33) | 40.57 ± 4.49 (0.44) | −2.69 ± 2.23 (−6.23) | <0.05 |
| Hexadecanoic acid (C16:0) | 2677.12 ± 200.2 (20.42) | 1365.59 ± 187.43 (14.91) | −1311.53 ± 101.87 (−48.99) | <0.00001 |
| Heptadecanoic acid (C17:0) | 85.22 ± 4.29 (0.65) | 80.65 ± 5.12 (0.88) | −4.57 ± 2.32 (−5.36) | <0.01 |
| Octadecanoic acid (C18:0) | 1162.88 ± 95.66 (8.87) | 614.02 ± 41.55 (6.70) | −548.86 ± 68.66 (−47.20) | <0.00001 |
| Eicosanoic acid (C20:0) | 44.58 ± 2.52 (0.34) | 39.76 ± 3.43 (0.43) | −4.81 ± 1.57 (−10.80) | <0.001 |
| Docosanoicacid (C22:0) | 111.44 ± 7.4 (0.85) | 98.11 ± 11.49 (1.07) | −13.33 ± 4.43 (−11.96) | <0.001 |
| Hexadecenoic acid (C16:1) n-7 | 283.18 ± 15.4 (2.16) | 253.18 ± 23.41 (2.76) | −30.00 ± 9.72 (−10.59) | <0.001 |
| Octadecenoic acid (c-C18:1) n-9 | 3265.78 ± 264.06 (24.91) | 1833.63 ± 175.47 (20.2) | −1432.17 ± 160.47 (−43.85) | <0.00001 |
| Eicosenoic acid (C20:1) n-9 | 85.22 ± 5.90 (0.65) | 76.34 ± 8.61 (0.83) | −8.68 ± 2.57 (−10.42) | <0.001 |
| Octadecadienoic acid (C18:2) n-6 | 2833.14 ± 192.36 (21.61) | 2425.03 ± 265.55 (26.48) | −408.11 ± 79.14 (−14.40) | <0.0001 |
| Eicosadienoic acid (C20:2) n-9 | 32.78 ± 4.17 (0.25) | 33.08 ± 3.09 (0.36) | 0.30 ± 1.49 (0.93) | 0.65 |
| Octadecatrienoic acid (C18:3) n-3 | 74.73 ± 5.38 (0.57) | 70.05 ± 5.71 (0.76) | −4.68 ± 1.10 (−6.26) | <0.01 |
| Eicosatrienoic acid (C20:3) n-6 | 166.50 ± 11.27 (1.27) | 170.57 ± 12.05 (1.86) | 4.07 ± 1.65 (2.44) | <0.01 |
| Eicosatetraenoic acid (C20:4) n-6 | 978.03 ± 82.0 (7.46) | 1005.83 ± 78.26 (10.98) | 27.80 ± 7.40 (2.84) | <0.001 |
| Docosatetraenoic acid (C22:4) n-6 | 89.15 ± 11.69 (0.68) | 91.48 ± 10.44 (1.00) | 2.33 ± 1.64 (2.61) | <0.05 |
| Docosapentenoic acid (C22:5) n-3 | 142.90 ± 11.21 (1.09) | 143.86 ± 11.66 (1.57) | 0.96 ± 0.61 (0.67) | <0.05 |
| Docosahexaenoic acid (C22:6) n-3 | 268.76 ± 18.8 (2.05) | 271.81 ± 18.53 (2.97) | 3.05 ± 1.35 (1.13) | <0.01 |
| FA trace | 335.62 ± 20.77 (2.56) | 325.49 ± 23.44 (3.55) | −10.13 ± 5.19 (−3.02) | <0.01 |
a
Mean ± SD.