Table 3.
The effect of rosuvastatin treatment on the individual concentration of free fatty acids in plasma.
| Free fatty acid | Absolute concentrationa, μmol/L (Relative concentration, %) |
Change from baseline (% mean change) | Effect, p value | |
|---|---|---|---|---|
| Baseline | Rosuvastatin | |||
| Dodecanoic acid (C12:0) | 15.74 ± 0.82 (2.32) | 12.33 ± 1.24 (2.30) | −3.41 ± 0.67 (−21.66) | <0.0001 |
| Tetradecanoic acid (C14:0) | 29.12 ± 2.05 (4.26) | 22.67 ± 3.03 (4.22) | −6.45 ± 1.22 (−22.15) | <0.0001 |
| Pentadecanoic acid (C15:0) | 5.33 ± 0.49 (0.78) | 4.21 ± 0.41 (0.78) | −1.12 ± 0.42 (−21.04) | <0.01 |
| Hexadecanoic acid (C16:0) | 170.96 ± 10.1 (25.01) | 131.40 ± 14.14 (24.46) | −39.56 ± 4.87 (−23.14) | <0.00001 |
| Heptadecanoic acid (C17:0) | 10.39 ± 0.78 (1.52) | 8.36 ± 1.17 (1.56) | −2.03 ± 0.56 (−19.54) | <0.001 |
| Octadecanoic acid (C18:0) | 68.56 ± 4.11 (10.03) | 53.24 ± 3.93 (9.91) | −15.32 ± 1.96 (−22.35) | <0.00001 |
| Eicosanoic acid (C20:0) | 3.76 ± 0.17 (0.55) | 2.89 ± 0.63 (0.54) | −0.87 ± 0.51 (−23.13) | <0.01 |
| Docosanoicacid (C22:0) | 7.93 ± 0.51 (1.16) | 6.18 ± 0.75 (1.15) | −1.75 ± 0.37 (−22.06) | <0.001 |
| Hexadecenoic acid (C16:1) n-7 | 21.46 ± 1.44 (3.14) | 16.83 ± 2.01 (3.13) | −4.63 ± 0.78 (−21.59) | <0.0001 |
| Octadecenoic acid (c-C18:1) n-9 | 228.44 ± 12.71 (33.42) | 178.51 ± 17.04 (33.23) | −49.93 ± 5.49 (−21.86) | <0.00001 |
| Eicosenoic acid (C20:1) n-9 | 5.61 ± 0.24 (0.82) | 4.36 ± 0.66 (0.81) | −1.25 ± 0.44 (−22.21) | <0.01 |
| Octadecadienoic acid (C18:2) n-6 | 92.60 ± 4.34 (13.53) | 73.71 ± 5.02 (13.72) | −18.89 ± 2.03 (−20.40) | <0.00001 |
| Eicosadienoic acid (C20:2) n-9 | 0.75 ± 0.02 (0.11) | 0.73 ± 0.12 (0.14) | −0.02 ± 0.10 (−2.91) | 0.62 |
| Octadecatrienoic acid (C18:3) n-3 | 1.51 ± 0.20 (0.22) | 1.19 ± 0.15 (0.22) | −0.32 ± 0.12 (−21.19) | <0.01 |
| Eicosatrienoic acid (C20:3) n-6 | 1.03 ± 0.04 (0.15) | 1.01 ± 0.15 (0.19) | −0.02 ± 0.12 (−1.49) | 0.69 |
| Eicosatetraenoic acid (C20:4) n-6 | 9.02 ± 0.49 (1.32) | 9.15 ± 0.69 (1.70) | 0.13 ± 0.22 (1.41) | 0.20 |
| Docosatetraenoic acid (C22:4) n-6 | 1.50 ± 0.07 (0.22) | 1.48 ± 0.28 (0.28) | −0.02 ± 0.22 (−1.58) | 0.83 |
| Docosapentenoic acid (C22:5) n-3 | 0.89 ± 0.04 (0.13) | 0.87 ± 0.01 (0.16) | −0.02 ± 0.07 (−2.09) | 0.64 |
| Docosahexaenoic acid (C22:6) n-3 | 1.64 ± 0.06 (0.24) | 1.67 ± 0.16 (0.31) | 0.03 ± 0.12 (1.80) | 0.58 |
| FA trace | 7.31 ± 0.21 (1.07) | 6.43 ± 0.85 (1.20) | −0.88 ± 0.66 (−12.09) | 0.023 |
a
Mean ± SD.