Table 2.

Fluid Balance by diuretic exposure in 48–72 h after meeting acute respiratory distress syndrome criteria

Patient characteristicsa (units)	No diuretic in 48–72 h after ARDS	Received diuretic in 48–72 h after ARDS	P value
Pre-ARDS ICU fluid balance (total L)	0.4 [0–2.8]	0.3 [0–3.4]	0.89
0–48 h after ARDS:
Daily fluid balance (L/24 h)	1.5 [0.4–2.7]	0.5 [−0.7–1.7]	<0.0001
Crystalloid intake (L/24 h)	1.2 [0.6–2.5]	0.6 [0.1–1.4]	<0.0001
Medication fluid intake (L/24 h)	1.1 [0.8–1.7]	1.1 [0.7–1.8]	0.92
Nutrition intake (L/24 h)	0.5 [0.1–1.1]	0.5 [0.2–1.0]	0.86
Free water intake (L/24 h)	0.1 [0–0.2]	0.1 [0–0.2]	0.39
Transfusion intake (L/24 h)	0 [0–0.1]	0 [0–0.1]	0.84
Total fluid output (L/24 h)	2.2 [1.4–3.4]	2.7 [1.9–3.4]	0.042
Net ICU fluid balance at 48 h (total L)	4.4 [1.6–7.8]	2.5 [−1.0–6.6]	0.0047
48–72 h after ARDS:
Daily fluid balance (L/24 h)	0.6 [−0.3–1.7]	−0.9 [−2.1–0.2]	<0.0001
Crystalloid intake (L/24 h)	0.3 [0–1.0]	0 [0–0.3]	0.0007
Less than 500 mL in 24 h	69 (59%)	84 (72%)	0.03
Free water intake (L/24 h)	0 [0–0.1]	0 [0–0.2]	0.17
Medication fluid intake (L/24 h)	0.9 [0.5–1.5]	1 [0.5–1.6]	0.6
Nutrition intake (L/24 h)	0.9 [0.2–1.5]	1.1 [0.4–1.6]	0.42
Free water intake (L/24 h)	0 [0–0.1]	0 [0–0.2]	0.17
Transfusion intake (L/24 h)	0 [0–0]	0 [0–0]	0.05
Total fluid output (L/24 h)	2.2 [1.6–2.9]	3.3 [2.4–4.5]	<.0001
Net ICU fluid balance at 72 h (Total L)	5.3 [1.6–9.4]	1.6[−2.3–6.1]	<0.0001

Volume overload is defined as a net ICU fluid balance (in L) equivalent to more than 10% of admission body weight (in kg)

Duration of MV refers to the duration in days of mechanical ventilation episode that includes ARDS onset

Abbreviations: ARDS acute respiratory distress syndrome, ICU intensive care unit

^aData shown as n (%), mean (standard deviation), or median [inter-quartile range] if not normally distributed