Table 1. Antiviral Data vs ZIKV in HepG2 Cells^a.

Compd	R1	R2	X	Survival % ± SD	Viability % ± SD
1	COOMe	Cl	C=O	47 ± 8	100 ± 14
2	COOEt	Br	C=O	66 ± 12	100 ± 4
3	COOEt	H	C=O	0	100 ± 2
4	COOEt	H	CH2	0	100 ± 5
5	COOMe	Br	C=O	22 ± 4	100 ± 7
6	COOMe	Br	CH2	2 ± 0.01	100 ± 6
7	COOEt	Br	CH2	20 ± 5	100 ± 7
8	Ph	Br	C=O	23 ± 8	100 ± 5
9	COOMe	Cl	CH2	23 ± 1	100 ± 3
10	COOMe	MeO	C=O	49 ± 6	100 ± 6
11	COOEt	MeO	C=O	47 ± 4	100 ± 4
12	COOEt	MeO	CH2	28 ± 2	100 ± 1
13	COOEt	OH	C=O	0	94 ± 4
14	COOMe	Cl	CH2	16 ± 1	100 ± 5
Ribab				82 ± 6	100 ± 1

^aCompounds were assayed at 10 μM. 1: IC₅₀ = 13.7 ± 2.7 μM; 2: IC₅₀ = 15.8 ± 0.9 μM. Experiments were performed in triplicate.

^bRibavirin was at 100 μM.