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| Compd | ZIKV Protease IC50 ± SD (μM)a | Huh-7 cells EC50 ± SD (μMM)b |
|---|---|---|
| 1c | 158 ± 25 | 13.9 ± 1.1 |
| 2 | 33 ± 7 | 16.2 ± 0.6 |
| 14 | 770 ± 210 | nd |
Activity of recombinant ZIKV protease measured through FRET assay.
Anti-ZIKV activity in Huh-7 infected cells line.
Under the same assay conditions, 1 inhibited the DENV2 protease with IC50 of 112 μM.
