Table 1. Tetrahydroisoquinoline Cores 2 (THIQ-thiazole) and 3 (THIQ-pyridine) and Selected Parameters.

Compound	BCL-XL FRET Ki (nM)	Solution Stability (pH 7.4, 37 °C)	eLogD7.4
		t1/2 (days)
2	65	58	3.02
3	164	63	2.85