. 2020 Mar 30;11(10):1829–1836. doi: 10.1021/acsmedchemlett.9b00568

Table 5. BCL-X_L and BCL-2 TR-FRET Binding Data and In Vitro Cell Efficacy of 1, 10, 12, and 13.

	BCL-X_L FRET K_i (nM)	BCL-2 FRET K_i (nM)	MOLT-4 EC₅₀ (nM, 10% HS)	RS4;11 EC₅₀ (nM, 10% HS)
1	<0.01	74.0	130	>5,000
10	0.027	69.8	1,610	>5,000
12	0.008	28.5	197	>5,000
13	<0.01	6.1	6.3	>5,000

Table 5. BCL-XL and BCL-2 TR-FRET Binding Data and In Vitro Cell Efficacy of 1, 10, 12, and 13.