. 2020 Mar 6;11(10):1820–1828. doi: 10.1021/acsmedchemlett.0c00006

Table 1. Inhibitory Activity for MC-180295 against Cyclin-Dependent Kinases^a.

target	CDK1/cyclin B	CDK2/cyclin A	CDK2/cyclin E	CDK3/cyclin E	CDK4/cyclin D	CDK5/P35	CDK5/P25	CdK8/cyclin D3	CDK7/CycH/MAT1	CDK9/cyclin T1
IC₅₀, nM	138	233	367	399	112	159	186	712	555	5

MC-180295 displayed 22.5-fold selectivity for CDK9 versus its next closest target, CDK4.⁸⁷

Table 1. Inhibitory Activity for MC-180295 against Cyclin-Dependent Kinasesa.