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Introduction to FAK protein and FAK-PROTACs. (a) FAK protein schematic. FAK-PROTACs can act on both enzymatic and nonenzymatic functions of FAK, while FAK inhibitor only acts on the enzymatic function of FAK. Y, phosphotyrosine; S, phosphoserine; *, autophosphorylation site (Tyr397); PR, proline-rich regions. (b) Schematic depiction of the PROTAC strategy.
