Skip to main content
. 2019 Oct 22;11(10):1855–1862. doi: 10.1021/acsmedchemlett.9b00372

Figure 4.

Figure 4

Highly potent and broad applicability of FC-11. (a) Half-maximal degradation concentrations (DC50) of FC-11 for FAK in different sources of cell lines. (b) Cellular FAK recovery levels after washout of FC-11 from PA1 cell culture medium. The cells were treated for 8 h before washout. (c) Efficiently decreased pFAKtyr397 levels at the indicated dose of FC-11 for 8 h in TM3 cells. FC-11 significantly exceeds PF562271 on decreasing the levels of pFAKtyr397. (d) Time course reduction of pFAKtyr397 in TM3 cells by FC-11.