Figure 6.

Schematic Model of TG/LDs Hydrolysis Mediated by Autophagy, Maintaining GBM Cell Energy Homeostasis and Survival

(A–C) GBM cells maintain energy homeostasis by utilizing glucose and TG/LDs. Under glucose-rich conditions, GBM cells mainly use glucose for energy production (A). Upon glucose starvation, autophagy is activated, which breaks down TG/LDs and releases the stored fatty acids that enter mitochondria for energy production (B). Blocking TG/LDs hydrolysis via inhibiting autophagy upon glucose reduction conditions will induce dramatic GBM cell death (C).