Predicted
binding mode of 5 to active and inactive
wtEGFR kinase domain. 5 was docked with AutoDock Vina
to active EGFR (PDB 1M17)18 as shown in (A), (B), and (C), and
to inactive EGFR (PDB 1XKK),36 as shown in (D), (E),
and (F). Color code: Cenzyme gray, O red, N blue, Cligand green, F light blue, Br dark red.