Table 5. Brain Penetration and in Vivo Parameters of Select Compounds^a.

^aAll brain and plasma AUC_0–7h determined after oral administration of 10 mg/kg in male CD-1 mice.

^bBrain/plasma ratios determined over 0–7 h.

^cRatio of the unbound concentration in the brain to that of plasma.

^dPermeability determined using MDCK-MDR1 cells.

^eRatio of P_app B-A/P_app A-B.