Fig. 2. Discovery of switch-II pocket binder. a, Chemical structures of the screening hits 2E07 (1) and ; 6H05 (2). b, Co-crystal structure of KRasG12C in the GDP state bound to compound 6Ostrem (3) (pdb id ; 4luc). c, Chemical structures of the vinyl sulfonamide compound 9Ostrem (4) and the acrylamide compound 12Ostrem (5). d, Co-crystal structure of KRasG12C in the GDP state bound to compound 12Ostrem (5) (pdb id ; 4lyh).
