Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 8;19:1533033820956988. doi: 10.1177/1533033820956988

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PMC Copyright notice

Figure 4. — DNA methylation inhibitors can reverse SENP3-induced methylation effects on E-Cad and cell phenotypes. (A, B) The DNA methylation inhibitors increased the expression of E-cad protein and reversed the SENP3-induced downregulation of E-Cad. (C) The DNA methylation inhibitors decreased the DNA methylation of E-Cad. (D) The DNA methylation inhibitors reversed SENP3-induced promotion of cell invasion of MG63 cells (5-aza-DC-treated group, p = 0.0008; Azartidine-treated group, p = 0.0006; 5-aza-DC + SENP3-treated group, p = 0.0003; Azartidine + SENP3-treated group, p = 0.0002). (E) The DNA methylation inhibitors reversed the SENP3-induced promotion of MG63 cell migration (5-aza-DC-treated group, p = 0.0076; Azartidine-treated group, p = 0.0113; 5-aza-DC + SENP3-treated group, p = 0.0008; Azartidine + SENP3-treated group, p = 0.0001). (F) The DNA methylation inhibitors reversed the SENP3-induced promotion of MG63 cell proliferation. (G) The DNA methylation inhibitors reversed the SENP3-induced apoptosis of MG63 cells (5-aza-DC-treated group, p = 0.0002; Azartidine-treated group, p = 0.0001; 5-aza-DC + SENP3-treated group, p = 0.0010; Azartidine + SENP3-treated group, p = 0.0003).