Figure 1.
Stereodiagram of the X-ray cocrystal structure of compound 3 bound in the active site of COX-2 (PDB code 6V3R). An omit map is contoured at 3σ in black mesh. The key residues are illustrated with a stick representation of the final model (carbon in yellow, oxygen in red, nitrogen in blue), and compound 3 is colored in green.