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. 2020 Jul 15;11(10):2017–2023. doi: 10.1021/acsmedchemlett.0c00176

Table 1. UUI and MIA of BBR, 1, and 2a.

graphic file with name ml0c00176_0007.jpg

Compound UUIa IC50 (μM) MIAb IC50 (μM) or %
BBR 6.8 3.1 μM
1 10.8 3.6 μM
2a 2.5 43%
a

UUI: Inhibitory activity of urate uptake into RPTECs.

b

MIA: Mitochondrial respiratory control ratio (RCR), IC50 (μM), or inhibition (%) at 100 μM.